Produced by Rob Cavallo (Green Day, My Chemical Romance), Big Whiskey has been hailed by Rolling Stone as the group’s "heaviest album yet, both musically and emotionally," which went on to note: "Throughout, Carter Beauford beats out elaborate, propulsive groves; bassist Stefan Lessard lays down Flea-style funk bass lines; violinist Boyd Tinsley plays cresting, intense runs; and Matthews mirrors Moore’s saxophone lines with scatlike singing." Billboard, in a cover story on Dave Matthews Band, praised Big Whiskey as "its best album yet… Highlights include the funk-rock rave-up 'Shake Me Like a Monkey,' the stirring ballad 'Lying in the Hands of God,' the swampy rocker 'Alligator Pie (Cockadile),' radio-friendly fare like 'Why I Am,' which features playful horns over a solid rock riff and a hooky chorus, and 'Funny the Way It Is,' which parlays a subtle intro into a soaring, syncopated anthem."
DVD content contains the making of "Big Whiskey and the Groogrux King".